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Implementing adherence to osteoporosis treatments.

Stefano Gonnelli¹, Laura Masi, Maria Luisa Brandi

¹Department of Internal Medicine, Endocrine-Metabolic Science and Biochemistry, University of Siena, Italy.

Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases

|March 31, 2012

Summary

Osteoporosis management requires long-term medication adherence. Improving patient adherence to osteoporosis treatments, like bisphosphonates (BPs), is crucial to prevent fractures and reduce healthcare costs.

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Area of Science:

Gerontology
Public Health
Pharmacology

Background:

Chronic diseases, including osteoporosis, represent a significant burden on Western healthcare systems due to prevalence and escalating costs.
Osteoporotic fractures are a leading cause of disability and a major contributor to healthcare expenditures globally, exacerbated by an aging population.
Effective pharmacological treatments for osteoporosis exist but necessitate long-term patient adherence for sustained efficacy.

Purpose of the Study:

To highlight the critical issue of poor medication adherence in osteoporosis treatment.
To underscore the link between non-adherence, increased fracture risk, hospitalization, and associated healthcare costs.
To emphasize the need for individualized strategies to improve patient adherence, involving physicians, particularly General Practitioners (GPs).

Main Methods:

Review of existing data on osteoporosis medication adherence rates.
Analysis of the consequences of non-adherence, including fracture incidence and healthcare utilization.
Discussion of factors influencing patient adherence and potential strategies for improvement.

Main Results:

High rates of non-adherence are observed, with a significant percentage of patients discontinuing bisphosphonates (BPs) within one year of daily or weekly treatment.
Poor adherence to osteoporosis medications is associated with a higher likelihood of fractures, leading to increased hospitalizations and healthcare costs.
Individual patient beliefs and circumstances significantly influence adherence, necessitating personalized intervention strategies.

Conclusions:

Improving long-term adherence to osteoporosis medications is essential for preventing fractures and managing healthcare costs.
Physicians, especially GPs, play a pivotal role in enhancing patient adherence through tailored strategies.
Emerging new drugs and innovative administration routes may offer future opportunities to support adherence initiatives.