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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Cells of the Adaptive Immune Response01:23

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.

Vu Quang Van1, Marianne Raymond, Nobuyasu Baba

  • 1Laboratoire d'Immunorégulation, Centre de Recherche du Hospitalier de l'Université de Montréal, l'Hôpital Notre-Dame, Montréal, Québec H2L 4M1, Canada.

Journal of Immunology (Baltimore, Md. : 1950)
|March 31, 2012
PubMed
Summary

CD47 expression levels identify precursors for long-lived memory CD4 T cells. High CD47 marks these progenitors, enabling functional memory T cells crucial for adaptive immunity and recall responses.

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07:39

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Published on: January 7, 2019

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • T cell memory is essential for adaptive immunity.
  • Identifying long-lived memory T cell precursors among effector T cells is a key challenge.
  • CD47 plays roles in cell death, elimination, and inflammation.

Purpose of the Study:

  • To investigate the role of CD47 expression dynamics in the development of functional memory CD4 T cells.
  • To determine if CD47 expression levels can identify memory T cell progenitors.

Main Methods:

  • Tracking CD47 expression on Ag-specific CD4 T cells during an in vivo immune response.
  • Assessing cytokine production by CD47(high) and CD47(low) effector T cells during recall responses.
  • Evaluating the capacity of CD47(high) and CD47(low) CD4 T cells to generate memory T cells upon adoptive transfer.

Main Results:

  • CD47 expression on Ag-specific CD4 T cells exhibited a transient pattern: CD47(high) -> CD47(low) -> CD47(high).
  • Early CD47(high) status identified central memory CD4 T cell precursors.
  • CD47(high) effector CD4 T cells produced cytokines during recall responses, unlike CD47(low) cells.
  • Transfer of CD47(high) CD4 T cells generated long-lived memory T cells capable of anamnestic responses.

Conclusions:

  • Transient CD47 expression dynamics are critical during immune responses.
  • CD47(high) status at an early time point marks functional, long-lived memory CD4 T cell progenitors.
  • CD47 serves as a reliable marker for identifying precursors of memory CD4 T cells.