Related Experiment Video
Updated: May 23, 2026

07:33
In Vitro Application of a Wireless Sensor in Flexion-Extension Gap Balance of Unicompartmental Knee Arthroplasty
Published on: May 5, 2023
Painful knee prosthesis: surgical approach.
Marco Villano1, Christian Carulli, Serena Puccini
1First Orthopaedic Clinic, University of Florence, Florence, Italy.
Summary
Diagnosing painful knee replacements can be challenging. Identifying causes like infection, loosening, or metal sensitivity is crucial for effective treatment and revision surgery.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Diagnostic Imaging
Background:
- Painful knee prostheses present a diagnostic challenge, with common causes including infection, aseptic loosening, instability, and arthropathy.
- Prosthetic infection requires prompt diagnosis and often a two-step revision, while aseptic loosening necessitates implant revision for stability.
- Instability and patellofemoral issues can stem from technical errors or component malalignment, requiring specialized implants or revision procedures.
Purpose of the Study:
- To review the diverse etiologies of painful knee prostheses.
- To outline diagnostic approaches for common and less common causes of prosthetic failure.
- To discuss treatment strategies, including revision surgery and management of metal sensitivity.
Main Methods:
- Review of literature on painful knee prosthesis diagnosis and management.
- Analysis of common failure modes: infection, aseptic loosening, instability, patellofemoral issues.
- Consideration of less common causes like referred pain, neuromas, and metal sensitization.
Main Results:
- Prosthetic infection is a primary consideration, managed with two-step revision.
- Aseptic loosening and instability often require implant revision, with implant choice depending on the type of instability.
- Patellofemoral pain may necessitate component evaluation, resurfacing, or revision due to tracking issues or malalignment.
- Unexplained pain may involve referred pain, ligament/tendon issues, neuromas, or metal sensitization, particularly to nickel.
Conclusions:
- Effective management of painful knee prostheses relies on accurate diagnosis of diverse causes, ranging from mechanical failures to biological responses.
- Prompt identification and treatment of prosthetic infection are critical.
- Metal sensitization, especially to nickel, is an underappreciated cause requiring minimal nickel content in revision implants.