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Inflammatory Bowel Disease II: Crohn's Disease

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Updated: May 23, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

Kohler's Disease.

Nirav Shastri1, Lauren Olson, Milton Fowler

  • 1University of Missouri-Kansas City, Children's Mercy Hospital and Clinics, Overland Park, Kansas.

The Western Journal of Emergency Medicine
|March 31, 2012
PubMed
Summary

This case report details a pediatric patient experiencing foot pain attributed to Kohler's disease. Early diagnosis and management are crucial for this rare pediatric bone condition.

Area of Science:

  • Pediatric Orthopedics
  • Pediatric Radiology
  • Pediatric Podiatry

Background:

  • Kohler's disease is a rare, self-limiting condition affecting the navicular bone in children.
  • It typically presents with foot pain and limping, often mistaken for other pediatric foot ailments.
  • Avascular necrosis of the navicular bone is the underlying pathology.

Purpose of the Study:

  • To present a pediatric case report of foot pain caused by Kohler's disease.
  • To highlight the diagnostic challenges and clinical presentation of this condition in children.
  • To emphasize the importance of timely diagnosis and appropriate management strategies.

Main Methods:

  • Case presentation of a pediatric patient with persistent foot pain.
  • Review of clinical findings, imaging studies (X-ray, MRI), and differential diagnoses.

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  • Discussion of the treatment approach and patient outcome.
  • Main Results:

    • The patient presented with characteristic symptoms of foot pain and tenderness.
    • Radiographic and MRI findings confirmed avascular necrosis of the navicular bone, consistent with Kohler's disease.
    • Conservative management led to symptom resolution and radiographic healing.

    Conclusions:

    • Kohler's disease is an important consideration in the differential diagnosis of pediatric foot pain.
    • Early recognition and conservative treatment are generally effective.
    • This case underscores the need for awareness among clinicians managing pediatric musculoskeletal complaints.