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Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits
Published on: June 2, 2019
Potential of Novel EPO Derivatives in Limb Ischemia
Dhiraj Joshi1, Janice Tsui, Rebekah Yu
1Vascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UK.
Abstract:
Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia.
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