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Updated: May 23, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
Chiroptical study of chiral discrimination by amino acid based ionic liquids
Daniel M Kroupa1, Christopher J Brown, Laurel M Heckman
1Department of Chemistry, Butler University , 4600 Sunset Avenue, Indianapolis, Indiana 46208, United States.
Abstract:
The chiral discrimination ability of amino acid based chiral ionic liquids is studied using chiroptical luminescence techniques. A racemic mixture of dissymmetric europium tris(2,6-pyridinedicarboxylate) complexes are dissolved in five chiral ionic liquids, including l- and d-alanine methyl ester bis(trifluoromethanesulfonimide), l-leucine methyl ester bis(trifluoromethanesulfonimide), l-proline methyl ester bis(trifluoromethanesulfonimide), and tetrabutylammonium l-alanate. Circularly polarized luminescence spectra are measured for the samples over the 283-323 K temperature range. Analysis of the spectroscopic results shows that the amino acid methyl ester chiral ionic liquids show discrimination with a preference (handedness) that corresponds to the stereoisomer (l- vs d-). Most of the chiral ionic liquids show enthalpically dominated discrimination, but l-leucine methyl ester bis(trifluoromethanesulfonimide) shows entropically dominated chiral discrimination.
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