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Bidirectional association between depression and sexual dysfunction: a systematic review and meta-analysis.
Evan Atlantis1, Thomas Sullivan
1Royal Adelaide Hospital/Institute of Medical and Veterinary Science, SA Health, Government of South Australia, Adelaide, SA, Australia. evan.atlantis@adelaide.edu.au
The Journal of Sexual Medicine
|April 3, 2012
Summary
Depression and sexual dysfunction share a two-way relationship. This study found depression increases sexual dysfunction risk, and sexual dysfunction significantly raises depression odds, highlighting the need for integrated screening and care.
Area of Science:
- Psychiatry
- Sexual Medicine
- Epidemiology
Background:
- Depression is commonly linked with sexual dysfunction in both genders.
- Understanding the predictive relationship between these conditions is crucial for effective clinical management.
Purpose of the Study:
- To investigate if depression predicts sexual dysfunction.
- To determine if sexual dysfunction predicts depression.
Main Methods:
- A systematic review and meta-analysis of prospective cohort studies.
- Searched PubMed and EMBASE databases up to November 2011.
- Pooled odds ratios (ORs) and relative risks (RRs) using random-effects models.
Main Results:
- Depression was associated with an increased risk of sexual dysfunction (adjusted RR/OR 1.71 [1.05, 2.78]).
- Sexual dysfunction significantly increased the odds of developing depression (adjusted OR 3.12 [1.66, 5.85]).
- Significant heterogeneity was noted in some analyses, but meta-regression did not identify significant sources.
Conclusions:
- A bidirectional association exists between depression and sexual dysfunction.
- Routine screening for depression in patients with sexual dysfunction, and vice versa, is recommended for clinicians.
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