Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cerebrospinal Fluid01:21

Cerebrospinal Fluid

Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Pegcetacoplan on Aqueous Humor Proteome in Geographic Atrophy: A Prospective Exploration.

Investigative ophthalmology & visual science·2025
Same author

Proteogenomic profiling of soft tissue leiomyosarcoma reveals distinct molecular subtypes with divergent outcomes and therapeutic vulnerabilities.

bioRxiv : the preprint server for biology·2025
Same author

Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport.

Immunity & ageing : I & A·2025
Same author

A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin.

Nucleic acids research·2025
Same author

Advances in multiple myeloma blood-based monitoring and its clinical applications.

Critical reviews in clinical laboratory sciences·2025
Same author

WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth.

Nature communications·2025

Related Experiment Video

Updated: May 23, 2026

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid
10:23

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid

Published on: December 4, 2017

The proteomic toolbox for studying cerebrospinal fluid.

Alain J van Gool1, Ronald C Hendrickson

  • 1Translational Medicine Research Centre Singapore, Merck Research Laboratories, MSD, Singapore. alain.vangool@tno.nl.

Expert Review of Proteomics
|April 3, 2012
PubMed
Summary

Cerebrospinal fluid (CSF) offers a promising source for discovering neurological biomarkers. This review explores the proteomic tools for CSF analysis in drug discovery, highlighting current trends and future challenges.

More Related Videos

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
08:23

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

Related Experiment Videos

Last Updated: May 23, 2026

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid
10:23

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid

Published on: December 4, 2017

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
08:23

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

Area of Science:

  • Neuroscience
  • Biochemistry
  • Drug Discovery

Background:

  • Cerebrospinal fluid (CSF) is a key biosample for biomarker discovery in neuroscience.
  • CSF contains proteomic and metabolomic markers reflecting neurological processes.
  • Biomarkers aid in diagnosing, prognosing, and evaluating drug efficacy.

Purpose of the Study:

  • To describe the proteomic toolbox for CSF analysis in drug discovery.
  • To outline current trends and future challenges in CSF biomarker research.

Main Methods:

  • Review of proteomic techniques applicable to CSF.
  • Analysis of CSF biomarker applications in preclinical and clinical settings.

Main Results:

  • CSF proteomic analysis provides insights into neurological states.
  • Biomarkers derived from CSF can inform patient stratification and drug development.

Conclusions:

  • CSF is a valuable resource for neuroscience biomarker discovery.
  • Advancements in proteomic tools are crucial for leveraging CSF in drug discovery.