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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

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Related Experiment Video

Updated: May 23, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
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Physical activity and circulating endothelial progenitor cells: an intervention study.

Francesca Cesari1, Francesco Sofi, Anna M Gori

  • 1Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy.

European Journal of Clinical Investigation
|April 3, 2012
PubMed
Summary

Personalized physical activity programs significantly reduce weight and fat mass in overweight and obese individuals. Adherence to these programs also increases circulating endothelial progenitor cells (EPCs), which correlate with fat mass reduction.

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Area of Science:

  • Cardiovascular Research
  • Exercise Physiology
  • Obesity Studies

Background:

  • Overweight and obesity are associated with impaired endothelial function.
  • Endothelial progenitor cells (EPCs) play a crucial role in vascular repair and angiogenesis.
  • Physical activity is a key intervention for managing weight and improving cardiovascular health.

Purpose of the Study:

  • To investigate the impact of a personalized physical activity program on body composition and circulating progenitor cells (CPCs) and EPCs in overweight and obese adults.
  • To determine if adherence to the program influences these outcomes.

Main Methods:

  • 80 overweight and obese subjects underwent a 3-month personalized physical activity program.
  • Measurements included anthropometrics, body composition, VO2max, and biochemical analyses at baseline (T0) and 3 months (T1).
  • CPCs and EPCs were quantified using flow cytometry.

Main Results:

  • Compliant individuals (n=47) showed significant reductions in weight (3.1%) and fat mass (4.4%).
  • Non-compliant individuals (n=33) experienced an increase in fat mass (1.5%).
  • Compliant individuals exhibited a significant increase in all measured EPC types and a trend for CPCs, with a correlation between decreased fat mass and increased CD133+/KDR+ EPCs.

Conclusions:

  • A 3-month personalized physical activity program effectively improves anthropometric measurements in overweight and obese individuals.
  • Increased EPC levels in compliant individuals are linked to weight loss, suggesting a beneficial vascular adaptation.