Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Other Stress Responses in Bacteria01:30

Other Stress Responses in Bacteria

Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expansion, functional diversification, and gene fusion events in the Ato protein family.

iScience·2026
Same author

Chaotic ghosts in systems with parameter drift: Delay and control critical transitions.

Physical review. E·2026
Same author

The prebiotic inulin affects virulence factor expression in <i>Candida albicans</i>.

mBio·2026
Same author

Compromising UDP-sugar nucleotide biosynthesis attenuates <i>Candida albicans</i> viability, virulence and drug sensitivity.

Cell surface (Amsterdam, Netherlands)·2026
Same author

<i>Galleria mellonella</i> as a versatile model for investigating <i>Candida glabrata</i> virulence and antifungal resistance.

Journal of medical microbiology·2026
Same author

Multiscale spatiotemporal neural network with multi-attention mechanism using brain partitioning for motor imagery recognition.

Journal of neuroscience methods·2026
Same journal

The clinical utility of bronchoalveolar lavage galactomannan result stewardship within a tertiary medical system.

Medical mycology·2026
Same journal

Cross-reactivity of Cryptococcal Antigen Lateral Flow Assay with Basidiomycetous Yeasts.

Medical mycology·2026
Same journal

Cryptococcus gattii complex infections in southern Brazil: epidemiology, clinical features, management and outcomes from a 33-year cohort.

Medical mycology·2026
Same journal

HAC1 contributes to stress adaptation and virulence in the emerging fungal pathogen Candida auris.

Medical mycology·2026
Same journal

Multicenter Study Reveals Alarming Terbinafine Resistance in Trichophyton indotineae Isolates from Iran.

Medical mycology·2026
Same journal

Human-to-animal transmission cases of the anthropophilic dermatophyte species Trichophyton tonsurans in France, 2021-2025.

Medical mycology·2026
See all related articles

Related Experiment Video

Updated: May 23, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Combinatorial stresses kill pathogenic Candida species.

Despoina Kaloriti1, Anna Tillmann, Emily Cook

  • 1School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, UK.

Medical Mycology
|April 3, 2012
PubMed
Summary
This summary is machine-generated.

Combinatorial stresses, like osmotic plus oxidative or oxidative plus nitrosative, are potent against pathogenic fungi Candida albicans and Candida glabrata. These findings suggest combined stresses are significant in host defenses against these yeasts.

More Related Videos

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
11:58

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

Related Experiment Videos

Last Updated: May 23, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
11:58

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

Area of Science:

  • Microbiology
  • Mycology
  • Pathogenesis

Background:

  • Pathogenic microbes, including Candida albicans and Candida glabrata, adapt to host environments through stress responses.
  • Individual stress responses (osmotic, oxidative, nitrosative) are well-studied, but combined effects are unknown.

Purpose of the Study:

  • To investigate the impact of combined environmental stresses on pathogenic fungi.
  • To compare the effects of combinatorial stresses with individual stresses in Candida glabrata and Candida albicans.

Main Methods:

  • Developed a common experimental platform for comparing stress responses.
  • Utilized buffered rich medium at 30°C to apply low, medium, and high doses of osmotic (NaCl), oxidative (H2O2), and nitrosative (DPTA-NONOate) stresses.
  • Compared the effects of individual and combined stresses on fungal growth and survival.

Main Results:

  • Certain combinations of osmotic plus oxidative stress, and oxidative plus nitrosative stress, were particularly effective at killing or inhibiting growth of C. albicans and C. glabrata.
  • Demonstrated for the first time the potent effects of specific combinatorial stresses.

Conclusions:

  • Combined stresses, particularly osmotic/oxidative and oxidative/nitrosative, significantly impact pathogenic yeast survival.
  • Combinatorial stresses may play a crucial role in host immune defenses against fungal infections.