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Updated: May 23, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Enterobacteriaceae producing the KPC-2 carbapenemase from hospital sewage
Xinzhuo Zhang1, Xiaoju Lü, Zhiyong Zong
1Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Abstract:
Fifteen isolates with reduced susceptibility to meropenem were obtained from hospital sewage. They contained bla(KPC-2) and belonged to multiple clones of Citrobacter freundii or Enterobacter cloacae. bla(KPC-2) was commonly carried by self-transmissible plasmids with different EcoRI-restricted patterns. Tn2 was identified upstream of bla(KPC-2), while ISKpn6 lay downstream. Hospital sewage could be an important reservoir of bla(KPC-2) and warrants more studies.
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