Related Experiment Video
Updated: May 23, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
Published on: December 19, 2025
Intra-arterial thrombolysis: tissue plasminogen activator and other thrombolytic agents
Edgar A Samaniego1, Italo Linfante, Guilherme Dabus
1Department of NeuroInterventional Surgery, Baptist Cardiac and Vascular Institute, Miami, FL 33176, USA.
Abstract:
Recanalization rates with the administration of intravenous tissue plasminogen activator in acute ischemic stroke are low. Adjuvant endovascular techniques that achieve recanalization by direct intra-arterial (IA) delivery of thrombolytics, mechanical clot retrieval, clot aspiration, and stenting may complement intravenous pharmacotherapy. IA thrombolytics can be administered within 6 hours of symptom onset in anterior circulation strokes and within 24 hours in posterior circulation strokes. This review describes the indications, patient selection, and technique for IA administration of thrombolytics.
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