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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Muscles of the Forearm that Move the Hand and Fingers01:16

Muscles of the Forearm that Move the Hand and Fingers

The muscles of the forearm that move the wrist, hand, and digits are numerous and diverse. They can be classified into two groups based on their location and function — the anterior and posterior compartment muscles.
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Chemical Synapses

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Related Experiment Video

Updated: May 23, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

Hand weakness in Charcot-Marie-Tooth disease 1X.

P J Arthur-Farraj1, S M Murphy, M Laura

  • 1MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. p.arthurfarraj@gmail.com

Neuromuscular Disorders : NMD
|April 3, 2012
PubMed
Summary
This summary is machine-generated.

Patients with Charcot-Marie-Tooth disease type 1X (CMT1X) often exhibit reduced hand strength. This study found that the dominant hand is weaker in CMT1X patients compared to their non-dominant hand.

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In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
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Related Experiment Videos

Last Updated: May 23, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

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Published on: January 7, 2019

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

Area of Science:

  • Neurology
  • Clinical Neuroscience
  • Peripheral Neuropathy

Background:

  • Previous research suggests patients with Charcot-Marie-Tooth disease (CMT) may have weaker dominant hand muscles.
  • Existing studies often analyze heterogeneous groups of CMT patients, limiting specific insights.
  • Charcot-Marie-Tooth disease type 1X (CMT1X) is a common inherited peripheral neuropathy.

Purpose of the Study:

  • To investigate hand muscle strength specifically in patients with CMT1X.
  • To determine if the dominant hand is weaker than the non-dominant hand in CMT1X.
  • To analyze electrophysiological measures in relation to hand dominance in CMT1X.

Main Methods:

  • Hand strength was assessed in 43 patients diagnosed with CMT1X.
  • Muscle strength was quantified using MRC scores for key hand muscles (first dorsal interosseous, abductor pollicis brevis).
  • Nerve conduction studies (median and ulnar nerves) were performed on both dominant and non-dominant hands.

Main Results:

  • Over half of CMT1X patients (51%) presented with a weaker dominant hand.
  • No patient exhibited a stronger dominant hand.
  • Significantly lower MRC scores and reduced median nerve compound motor action potentials were observed in the dominant hand compared to the non-dominant hand.

Conclusions:

  • The dominant hand is demonstrably weaker than the non-dominant hand in individuals with CMT1X.
  • These findings highlight a specific pattern of muscle weakness in CMT1X affecting hand dominance.
  • Further research may explore the implications of this dominant hand weakness for functional activities in CMT1X patients.