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[Rational control on postoperative blood glucose levels in infants with congenital heart disease]

Mei Liu1, Ping Zheng, Xiao-ying Zheng

  • 1Intensive Care Unit, Shenzhen Second People's Hospital, Shenzhen 518000, Guangdong, China. mei_l82@qq.com

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue
|April 3, 2012
PubMed

Insights

Intensive blood glucose control in infants undergoing heart surgery may increase hypoglycemia risk. Active control balances benefits and risks, reducing infection markers without significant hypoglycemia.

Area of Science:

  • Pediatric Cardiology
  • Critical Care Medicine
  • Metabolic Disorders

Context:

  • Congenital heart disease (CHD) necessitates open-heart surgery in infants.
  • Post-operative hyperglycemia is a concern in these vulnerable patients.
  • Optimal blood glucose management strategies require investigation.

Purpose:

  • To determine the ideal post-operative blood glucose control level for infants with congenital heart disease (CHD).
  • To compare the effects of intensive, active, and common glucose control strategies on post-operative outcomes.

Summary:

  • 102 infants undergoing open-heart surgery were randomized into intensive (A), active (B), and common (C) glucose control groups.
  • Group A targeted glucose levels ≤8.3 mmol/L, Group B ≤15.0 mmol/L, and Group C ≤18.0 mmol/L.
  • Outcomes including white blood cell count (WBC), C-reactive protein (CRP), pulmonary infection, hypoglycemia, and liver function were assessed.

Impact:

  • Severe hyperglycemia correlated with increased WBC, CRP, and pulmonary infection rates.
  • Intensive control (Group A) led to higher hypoglycemia incidence.
  • Active control (Group B) showed promise by reducing ALT levels and infection markers without significant hypoglycemia risk.
Abstract

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