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Diethylstilboestrol--a long-term legacy

R M Harris1, R H Waring

  • 1School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Maturitas
|April 3, 2012
PubMed

Insights

Diethylstilboestrol (DES) is an endocrine-disrupting chemical linked to cancers and reproductive abnormalities in humans. Its widespread use in medicine and agriculture raises concerns about population-wide exposure and potential epigenetic effects.

Area of Science:

  • Endocrinology
  • Environmental Health
  • Toxicology

Background:

  • Diethylstilboestrol (DES) is a synthetic estrogen with endocrine-disrupting properties.
  • DES was widely prescribed for gynecological issues and used in livestock, leading to potential human exposure.
  • Observed health issues in DES-exposed offspring include rare cancers and genital abnormalities.

Purpose of the Study:

  • To review the evidence on Diethylstilboestrol (DES) as an endocrine disruptor.
  • To explore the mechanisms of DES-induced carcinogenesis and epigenetic effects.
  • To assess the potential role of DES as an obesogen in human populations.

Main Methods:

  • Literature review of epidemiological studies and animal research on DES.
  • Analysis of documented health outcomes in individuals exposed to DES.
  • Evaluation of proposed mechanisms of endocrine disruption and carcinogenesis.

Main Results:

  • DES exposure is associated with an increased risk of specific cancers, such as clear cell adenocarcinoma.
  • Evidence suggests DES can induce epigenetic modifications in exposed individuals.
  • Potential links between DES exposure and increased obesity rates are being investigated.

Conclusions:

  • Diethylstilboestrol (DES) poses significant health risks due to its endocrine-disrupting and carcinogenic potential.
  • Epigenetic effects and obesogenic properties warrant further investigation.
  • Minimizing exposure to endocrine disruptors like DES is crucial for public health.

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