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Related Concept Videos

Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral stimuli,...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.

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Related Experiment Video

Updated: May 23, 2026

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
14:08

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

Elf5, hormones and cell fate.

Heather J Lee1, Christopher J Ormandy

  • 1Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia.

Trends in Endocrinology and Metabolism: TEM
|April 3, 2012
PubMed
Summary

Understanding stem cell hierarchies in development reveals disease insights. The ETS transcription factor Elf5 acts as a crucial gatekeeper, regulating cell fate and development, with implications for diseases like cancer.

Area of Science:

  • Developmental biology
  • Molecular genetics
  • Cancer research

Background:

  • Stem and progenitor cell hierarchies are crucial for normal tissue development.
  • Genetic mechanisms control cell fate and act as essential gatekeepers for organism viability.
  • Disruptions in these gatekeeper functions are linked to developmental diseases, including cancer.

Purpose of the Study:

  • To review the regulatory roles of the ETS transcription factor Elf5.
  • To explore Elf5's function as a gatekeeper in diverse developmental contexts.
  • To elucidate the intersection of Elf5's function with hormonal and growth factor signaling.

Main Methods:

  • Literature review of developmental biology studies.
  • Analysis of genetic mechanisms controlling cell fate.

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Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans
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Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans

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Last Updated: May 23, 2026

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
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Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
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Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

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  • Examination of Elf5's role in various developmental scenarios.

    • Main Results:

    • Elf5 acts as a master regulator and gatekeeper in multiple developmental processes.
    • Elf5's function is integrated with hormonal and growth factor signaling pathways.
    • Perturbation of Elf5's gatekeeper role is implicated in disease pathogenesis.

    Conclusions:

    • Elf5 is a key regulator of cell fate and development.
    • Understanding Elf5's role provides insights into developmental diseases like cancer.
    • Elf5 represents a potential target for therapeutic interventions in related diseases.