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Related Concept Videos

Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Essential Minerals for Bone Health

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Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model
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Published on: September 27, 2024

Does complement play a role in bone development and regeneration?

Philipp Schoengraf1, John D Lambris, Stefan Recknagel

  • 1Institute of Orthopaedic Research and Biomechanics, Centre of Muskuloskelettal Research, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany.

Immunobiology
|April 3, 2012
PubMed
Summary
This summary is machine-generated.

The skeletal and immune systems interact, with the complement system linking bone health and immunity. This review explores their mutual regulation and risks of excessive complement activation.

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Last Updated: May 23, 2026

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

  • Immunology
  • Skeletal Biology
  • Bone Homeostasis

Background:

  • The skeletal and immune systems are intricately linked, not independent.
  • Shared cytokines and cell types facilitate complex interactions.
  • The complement system, part of innate immunity, acts as a key mediator.

Purpose of the Study:

  • To review the multifaceted interactions between the skeletal and immune systems.
  • To elucidate the role of the complement system in bone biology.
  • To highlight negative consequences of dysregulated complement activation.

Main Methods:

  • Literature review of existing research on bone-immune system interactions.
  • Analysis of the role of complement proteins in bone homeostasis.
  • Examination of osteoblast and osteoclast activity influenced by complement.

Main Results:

  • Complement proteins are integral to bone development and homeostasis.
  • Complement system significantly influences osteoblast and osteoclast function.
  • Inappropriate or excessive complement activation can lead to adverse effects.

Conclusions:

  • The skeletal and immune systems engage in complex, mutual regulation.
  • The complement system is a critical link in bone-immune crosstalk.
  • Understanding these interactions is vital for managing bone-related immune disorders.