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Related Experiment Video

Updated: May 23, 2026

Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation

Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation

Published on: May 22, 2017

Novel HDL-based therapeutic agents.

¹Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5K8. tisjoy@hotmail.com

Pharmacology & Therapeutics

|April 3, 2012

Summary

This summary is machine-generated.

New therapies aim to boost high-density lipoprotein cholesterol (HDL-C) or improve its function to further reduce cardiovascular disease risk, beyond lowering LDL-C. This review covers novel agents targeting HDL-C.

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Formulation and Characterization of Bioactive Agent Containing Nanodisks

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Last Updated: May 23, 2026

Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation

Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation

Published on: May 22, 2017

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Area of Science:

Cardiovascular Medicine
Pharmacology
Lipid Metabolism

Background:

Lowering low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular disease (CVD) risk by 25-30%, yet residual risk persists.
Low high-density lipoprotein cholesterol (HDL-C) levels are linked to increased CVD risk.
Novel therapeutic strategies are needed to address residual CVD risk by targeting HDL-C.

Purpose of the Study:

To review emerging therapeutic agents designed to increase HDL-C levels or enhance HDL functionality.
To provide an overview of the mechanisms of action, pharmacokinetics, and efficacy/safety data for these novel therapies.

Main Methods:

Review of current literature on novel HDL-C-targeting therapies.
Analysis of therapeutic classes including cholesteryl ester transfer protein (CETP) inhibitors, apolipoprotein A-I (apoA-I) mimetics, RVX-208, and apoA-I based infusion therapies.

Main Results:

Discussion of CETP inhibitors, apoA-I mimetics, RVX-208, and apoA-I infusion therapies.
Presentation of mechanism of action, pharmacokinetic profiles, and clinical trial data (efficacy and safety) for each agent class.

Conclusions:

Emerging therapies targeting HDL-C offer potential for further cardiovascular risk reduction.
Further research and clinical validation are necessary to establish the role of these agents in managing cardiovascular disease.