Related Experiment Video
Updated: Sep 1, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Prognostic value of matrix metalloproteinase 9 expression in patients with non-small cell lung cancer
Wen-Jia Peng1, Jun-Qing Zhang, Bing-Xiang Wang
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Background:
The role of matrix metalloproteinase 9 (MMP-9) expression in non-small cell lung cancer (NSCLC) remains controversial. We performed a systematic review of the literature with meta-analysis.
Methods:
Electronic databases were used to identify published studies before December 1, 2011. Pooled hazard ratio (HR) with 95% confidence interval (95% CI) was used to estimate the strength of the association between MMP-9 expression survival of NSCLC patients. Heterogeneity and publication bias were also assessed.
Results:
The final analysis of 2029 NSCLC cases from 17 studies is presented. The combined HR of 1.84 (95% CI: 1.62-2.09) suggested that MMP-9 over-expression had a poor prognosis in patients with NSCLC. Subgroup analyses also detected significant association. Heterogeneity and publication bias was absent in current meta-analysis. Sensitivity analyses suggested that the summary statistics obtained should approximate the actual average.
Conclusion:
High MMP-9 expression is associated with a poor prognosis in patients with NSCLC.