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Published on: July 28, 2016
Serum myeloperoxidase activity and oxidative stress in patients with acute brucellosis
Mustafa Kasım Karahocagil1, Mehmet Aslan, Mehmet Resat Ceylan
1Yuzuncu Yıl University, Medical Faculty, Department of Infectious Disease and Clinical Microbiology, Van, Turkey.
Objectives:
The role of infection in the pathogenesis of atherosclerosis has been increasingly discussed. Previous studies have suggested that increased myeloperoxidase activity plays an important role in the pathogenesis of atherosclerosis. The aim of this study was to investigate the serum myeloperoxidase activity and catalase activity along with lipid hydroperoxide (LOOH) levels in patients with acute brucellosis.
Design And Methods:
Thirty-two patients with brucellosis and 33 healthy controls were enrolled. Serum myeloperoxidase activity, catalase activity and LOOH levels were determined.
Results:
Serum myeloperoxidase activity and LOOH levels were significantly higher in patients with brucellosis than controls (p<0.05, p<0.001), while catalase activity were significantly lower (p<0.001). LOOH levels were found to be significantly positively correlated with MPO activity (r=0.297, p=0.016) in patients.
Conclusions:
These results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients.
Insights
Acute brucellosis infection is linked to higher myeloperoxidase activity and lipid hydroperoxide levels, indicating increased oxidative stress that may contribute to atherosclerosis.
Area of Science:
- Infectious Diseases
- Cardiovascular Research
- Biochemistry
Background:
- Infection's role in atherosclerosis is increasingly recognized.
- Myeloperoxidase (MPO) activity is implicated in atherosclerotic pathogenesis.
- Brucellosis is an infectious disease with potential systemic effects.
Purpose of the Study:
- To investigate serum MPO activity, catalase activity, and lipid hydroperoxide (LOOH) levels in acute brucellosis patients.
- To explore the relationship between these oxidative stress markers and brucellosis.
Main Methods:
- A case-control study involving 32 patients with brucellosis and 33 healthy controls.
- Measurement of serum MPO activity, catalase activity, and LOOH levels.
Main Results:
- Patients with brucellosis exhibited significantly higher serum MPO activity and LOOH levels compared to controls.
- Catalase activity was significantly lower in brucellosis patients.
- LOOH levels showed a significant positive correlation with MPO activity in patients.
Conclusions:
- Elevated MPO activity and reduced catalase activity in brucellosis are associated with increased oxidative stress.
- This oxidative stress may play a role in the atherosclerotic processes observed in brucellosis patients.
