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Updated: May 23, 2026

Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug
Published on: December 14, 2021
[Internal jugular venous cannulation: what is the best approach?]
T Lamkinsi1, A Kettani, Z Belkhadir
1Laboratoire de génétique et biométrie, faculté des Sciences, université Ibn Tofail, BP 133, Kénitra, Maroc. tlamkinsi@hotmail.com
Objectives:
The aim of this study was to compare two approaches used for internal jugular venous cannulation: the anterior way, described by English et al. and the posterior way, described by Jernigan et al. The primary endpoint was the rate of success. The secondary endpoints were the related adverse events and the difficulty factors.
Study Design:
Prospective, randomized open clinical trial.
Patients And Methods:
The study took place in the vital emergency room, the operating room and the emergency intensive care unit of Ibn Sina University hospital (Rabat, Morocco), between June and September 2010. Hundred and one patients needing a central venous catheter were randomized to undergo one of the two techniques. We compared: demographics, success rates, number of attempts, difficulty factors and adverse events.
Results:
The success rate was significantly higher in the posterior group (96% versus 68%, P < 0.001), with fewer attempts (1.3 ± 0.7 versus 2.1 ± 1.3; P < 0.001). There were less pneumothorax, (0 versus 6%) and more accidental arterial punctures (34 versus 25.5%) in the posterior group, but the difference wasn't significant. Finally, none of the difficulty factors were correlated to the failure rate.
Conclusion:
This study shows that the posterior approach in internal jugular venous cannulation is more efficient than and as safe as the anterior approach.
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