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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

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Updated: May 23, 2026

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Reservoir-based drug delivery systems utilizing microtechnology.

Cynthia L Stevenson1, John T Santini, Robert Langer

  • 1On Demand Therapeutics, Inc., One Industrial Way, Unit 1A, Tyngsboro, MA 01879, USA. cstevenson@ondemandtx.com

Advanced Drug Delivery Reviews
|April 3, 2012
PubMed
Summary
This summary is machine-generated.

Microtechnology enhances reservoir-based drug delivery systems for oral, dermal, and implantable applications. These systems offer controlled drug release, improved stability, and versatile dosing for advanced patient therapies.

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Microinjectrode System for Combined Drug Infusion and Electrophysiology
08:30

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

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Last Updated: May 23, 2026

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Microinjectrode System for Combined Drug Infusion and Electrophysiology
08:30

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmaceutics

Background:

  • Reservoir-based drug delivery systems are crucial for controlled and sustained release of therapeutics.
  • Microtechnology offers advanced fabrication and miniaturization capabilities for drug delivery devices.

Purpose of the Study:

  • To review reservoir-based drug delivery systems utilizing microtechnology.
  • To highlight oral, dermal, and implantable applications of these systems.

Main Methods:

  • Review of microfabricated reservoir-based drug delivery systems.
  • Analysis of working principles, fabrication methods, dimensional constraints, and performance criteria.

Main Results:

  • Microtechnology enables precise control over drug formulation and release kinetics.
  • Reservoir systems provide enhanced drug stability and prolonged delivery durations.
  • Systems accommodate diverse delivery profiles: zero-order, pulsatile, and on-demand dosing.

Conclusions:

  • Microreservoir systems offer significant advantages over traditional drug delivery methods.
  • These advanced systems hold potential for targeted delivery in challenging therapeutic areas.
  • Development paves the way for innovative patient therapies with improved outcomes.