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Updated: May 23, 2026
A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
Development of electrochemiluminescence-based singleplex and multiplex assays for the quantification of α-synuclein
Niels Kruse1, Walter J Schulz-Schaeffer, Michael G Schlossmacher
1Institute for Neuropathology, Prion and Dementia Research Unit, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Goettingen, Germany. n.kruse@med.uni-goettingen.de
Abstract:
The need for improved diagnostic accuracy and markers of progression in neurodegenerative diseases motivates the identification of objective biomarkers as well as optimized assays for their quantification. Several potential marker candidates for Parkinson's disease (PD) in cerebrospinal fluid have been identified. These include α-synuclein, a major constituent of the intracellular aggregates. We give a general overview and details of our experience in converting established enzyme-linked immunoabsorbent assays (for α-synuclein and other proteins) onto an electrochemiluminescence-based platform as well as considerations on multiplexing different assays for PD.
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