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Updated: May 23, 2026
04:59
Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
Published on: September 27, 2019
Peripheral mechanisms of itch
Benjamin McNeil1, Xinzhong Dong
1The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Neuroscience Bulletin
|April 3, 2012
Summary
This review explores itch (pruritus) sensation, focusing on ligands and receptors activating sensory neurons. It also discusses indirect itch inducers and neurotransmitters involved in itch signal propagation.
Area of Science:
- Neuroscience
- Dermatology
- Sensory Biology
Background:
- Environmental stimuli detection involves peripheral receptors.
- Itch (pruritus) is an understudied aversive sensation.
- Understanding itch mechanisms is crucial for managing related conditions.
Purpose of the Study:
- To review ligands and receptors initiating itch sensation.
- To explore indirect mechanisms of itch induction.
- To discuss neurotransmitters in itch signal transmission.
Main Methods:
- Literature review of scientific publications.
- Analysis of known itch-inducing ligands and receptors.
- Examination of indirect signaling pathways.
Main Results:
- Identified key ligands and receptors activating primary sensory neurons for itch.
- Highlighted substances acting indirectly via other cell types.
- Discussed progress in identifying itch neurotransmitters.
Conclusions:
- Primary sensory neuron activation is central to itch.
- Indirect pathways contribute significantly to itch perception.
- Further research on neurotransmitters is needed for a complete understanding of itch.
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