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In vitro bactericidal activity against periodontopathic bacteria by electrolyzed ion-reduced water
M Okajima1, M Kanzaki, Y Ishibashi
1Department of Pharmaceutical Sciences, Meiji Pharmaceutical University, Tokyo, Japan.
Drug Discoveries & Therapeutics
|April 3, 2012
Summary
Electrolyzed ion-reduced water (ERI) rapidly kills over 99% of common periodontal bacteria, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. ERI shows promise for preventing and treating periodontal diseases.
Area of Science:
- Microbiology
- Periodontology
- Biochemistry
Background:
- Periodontal diseases are often caused by bacteria like Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.
- Effective treatments are crucial for managing these infections.
Purpose of the Study:
- To evaluate the bactericidal efficacy of electrolyzed ion-reduced water (ERI) against P. gingivalis and A. actinomycetemcomitans.
- To assess the impact of sodium carboxymethylcellulose (CMC-Na) on ERI's antimicrobial activity.
Main Methods:
- Exposure of P. gingivalis and A. actinomycetemcomitans to ERI and ERI-1% CMC-Na.
- Evaluation of the time course and concentration-dependent bactericidal effects.
Main Results:
- Over 99% of both bacterial species were killed within 15 seconds by ERI and ERI-1% CMC-Na.
- The addition of 1% CMC-Na did not inhibit ERI's bactericidal action.
- ERI demonstrated concentration-dependent killing, with P. gingivalis eradicated at 15% and A. actinomycetemcomitans at 50% concentration.
Conclusions:
- ERI exhibits rapid and potent bactericidal activity against key periodontal pathogens.
- ERI is a potential therapeutic agent for the prevention and treatment of periodontal diseases.
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