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A case of isoniazid-induced thrombocytopenia: recovery with immunoglobulin therapy

Eun Ju Lee1, Seung Hun Lee, You Eun Kim

  • 1Department of Internal Medicine, College of Medicine, Gyeongsang National University, Korea.

Internal Medicine (Tokyo, Japan)
|April 3, 2012
PubMed

Treatment for a 51-year-old man with pulmonary tuberculosis was initiated with isoniazid, rifampicin, ethambutol, and pyrazinamide, and discontinued after 3 weeks because of skin rash and itchiness. Isoniazid monotherapy was restarted after 2 weeks. Two days later, the platelet count decreased from 150 to 4×10(3)/mm(3). Despite platelet transfusion and oral corticosteroid treatment, the platelet count did not recover. However, after a 2-day administration of intravenous immunoglobulin, the platelet count recovered to 209×10(3)/mm(3). This report describes a case of isoniazid-induced thrombocytopenia that was reversed with intravenous immunoglobulin, thus highlighting the efficacy of this treatment for this rare condition.

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