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Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through

Ayako Arai1, Ken-ichi Imadome, Ludan Wang

  • 1Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan. ara.hema@tmd.ac.jp

Internal Medicine (Tokyo, Japan)
|April 3, 2012
PubMed

We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed from that detected before BMT. These findings indicated that her disease had developed from donor cells. This is the first report of donor cell-derived CAEBV that recurred after transplantation, suggesting that host factors may be responsible for the development of this disease.

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