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Published on: February 23, 2017
Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid
Marija Ð Vukelić1, Žarko J Mitić, Miroslav S Miljkovic
1Institute of Biology and Human Genetics, Faculty of Medicine, University of Nis, Serbia. marijavukelic@medfak.ni.ac.rs
Unlabelled:
Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma.
Purpose:
This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-dl-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material.
Methods:
N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement.
Results:
Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material.
Conclusions:
The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considered crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration.
