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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Related Experiment Video

Updated: May 23, 2026

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

Published on: March 15, 2011

Genomic microarrays: a technology overview.

Paul D Brady¹, Joris R Vermeesch

¹Laboratory for Cytogenetics and Genome Research, Centre for Human Genetics, University Hospital Leuven, K.U. Leuven, Leuven, Belgium.

Prenatal Diagnosis

|April 3, 2012

Summary

This summary is machine-generated.

Genomic microarrays are essential for diagnosing intellectual disability, congenital anomalies, and autistic spectrum disorder. This technology also aids in detecting genomic imbalances during prenatal diagnosis.

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DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

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Area of Science:

Genomics
Molecular Diagnostics
Medical Genetics

Background:

Genomic microarrays are increasingly utilized in clinical diagnostics.
Applications include molecular karyotyping for developmental disorders and prenatal genetic analysis.

Purpose of the Study:

To provide an overview of genomic microarray technologies.
To discuss the protocols and data analysis methods for genomic arrays.

Main Methods:

Review of different genomic array platforms.
Description of standard laboratory protocols for array analysis.
Discussion of computational methods for interpreting array data.

Main Results:

Genomic microarrays enable precise detection of chromosomal abnormalities.
Established protocols facilitate routine diagnostic use.
Various data analysis strategies exist for robust interpretation.

Conclusions:

Genomic microarrays are a powerful tool for diagnosing genetic disorders.
Standardized approaches enhance their clinical utility.
Further advancements in data analysis will improve diagnostic yield.