Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Risk of Major Malformations Following First-Trimester Exposure to Cariprazine: Preliminary Data From the MGH National Pregnancy Registry for Psychiatric Medications.

Bipolar disorders·2026

Same author

A digital microfluidic platform for cell-based non-invasive testing.

iScience·2026

Same author

A next-generation episignature for Kabuki syndrome enables fine mapping of the impact of KMT2D variants to inform precision medicine.

American journal of human genetics·2026

Same author

Pathogenic variants in BORCS5 cause a spectrum of neurodevelopmental and neurodegenerative disorders with lysosomal dysfunction.

The Journal of clinical investigation·2026

Same author

Diagnostic yield and imaging: aetiology correlations in prenatal intracranial haemorrhage-a retrospective cohort study.

Archives of disease in childhood. Fetal and neonatal edition·2026

Same author

Examining aspects of job satisfaction associated with burnout and factors related to turnover intention in genetic counselors.

Journal of genetic counseling·2026

Same journal

Fetoscopic Vesicostomy for Lower Urinary Tract Obstruction: A Proposal for a New Surgical Technique.

Prenatal diagnosis·2026

Same journal

Performance of a Flexible Versus Rigid Fetoscope in the Simulated Management of Twin-to-Twin Transfusion Syndrome.

Prenatal diagnosis·2026

Same journal

Thickened Nuchal Translucency, Lymphangioma, and Ventriculomegaly: Prenatal Phenotypes for MSL2-Related Disorders.

Prenatal diagnosis·2026

Same journal

Genomic Landscape and Perinatal Outcomes of Fetal Polydactyly: A Retrospective Cohort Study Integrating CNV-seq and Trio-ES.

Prenatal diagnosis·2026

Same journal

Detecting Androgenetic Origin of the Genome via Single-Nucleotide Polymorphism-Based Cell-Free DNA Screening in Dichorionic Diamniotic Twin Pregnancies With Complete Hydatidiform Moles and a Coexisting Normal Fetus: A Three-Case Report.

Prenatal diagnosis·2026

Same journal

Structural Variation Sequencing of 26 Amniotic Fluid Samples With Partial Gene Duplications and Postnatal Follow-Up of the Fetuses.

Prenatal diagnosis·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 23, 2026

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Referral patterns for microarray testing in prenatal diagnosis.

Lisa G Shaffer¹, Mindy Preston Dabell, Jill A Rosenfeld

¹Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, WA, USA. lisa.shaffer@perkinelmer.com

Prenatal Diagnosis

|April 3, 2012

Summary

This summary is machine-generated.

Prenatal whole-genome microarray usage varies by country and indication. Lower resolution arrays detect most significant abnormalities, informing future prenatal testing array design.

More Related Videos

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Related Experiment Videos

Last Updated: May 23, 2026

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Area of Science:

Genetics
Prenatal Diagnostics

Background:

Whole-genome microarrays are used for prenatal genetic analysis.
Different array resolutions offer varying detection capabilities.

Purpose of the Study:

To compare prenatal referral patterns for two whole-genome microarray platforms with different resolutions in the US, Canada, and Israel.
To analyze detection rates, referral indications, and array selection by physicians.

Main Methods:

Retrospective analysis of 1483 prenatal specimens over one year.
Comparison of two whole-genome microarray platforms: 55K (lower resolution) and 135K (higher resolution).
Examination of physician array selection based on referral indications.

Main Results:

The 55K array detected all but one significant abnormality found by the 135K array, with a 32% reduction in detecting unclear results.
Abnormal ultrasound findings were the primary referral reason, with the US and Canada favoring the 135K array, while Israel preferred the 55K array.
Referrals for parental anxiety predominantly used the 55K array, while advanced maternal age and family history were infrequent referral reasons.

Conclusions:

Significant international and indication-specific variations exist in prenatal microarray referral patterns.
Understanding these differences is crucial for developing tailored microarray designs that meet clinical needs and patient expectations for prenatal testing.