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Updated: May 23, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
12:03

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Published on: June 7, 2016

Angiotensin receptor blockers and tumorigenesis: something to be (or not to be) concerned about?

Vadim Tchaikovski1, Gregory Y H Lip

  • 1Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, City Hospital Birmingham, Birmingham, B18 7QH, England, UK.

Current Hypertension Reports
|April 3, 2012
PubMed

Insights

Concerns about cancer risks with antihypertensive drugs, specifically angiotensin receptor blockers (ARBs), have resurfaced. This review synthesizes current evidence to assess if ARBs increase cancer risk.

Area of Science:

  • Pharmacology and Oncology
  • Cardiovascular Drug Safety

Background:

  • Antihypertensive therapies, particularly angiotensin receptor blockers (ARBs), have faced scrutiny regarding potential carcinogenic side effects.
  • Regulatory bodies in the US and Europe have re-examined evidence linking ARBs to cancer risk.

Purpose of the Study:

  • To comprehensively review and synthesize current multidisciplinary evidence on the association between ARBs and tumorigenesis.
  • To address the ongoing debate regarding the safety of ARBs concerning cancer development.

Main Methods:

  • Review of existing scientific literature, including basic science and preclinical studies.
  • Analysis of data from three meta-analyses and one nationwide cohort study.
  • Synthesis of contemporary, multidisciplinary evidence.

Main Results:

  • Evidence from basic science, preclinical studies, meta-analyses, and cohort studies was evaluated.
  • The review consolidates findings to assess the link between ARBs and cancer risk.
  • Contemporary data is summarized to inform the ongoing safety discussion.

Conclusions:

  • The review provides a summary of current evidence regarding ARBs and cancer risk.
  • It aims to clarify the association between this class of antihypertensive medications and potential tumorigenesis.
  • Findings will contribute to the ongoing assessment of ARB safety by regulatory agencies and clinicians.

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