DeOri: a database of eukaryotic DNA replication origins

Area of Science:

• Molecular Biology
• Genomics
• Cell Biology

Background:

• DNA replication is fundamental for cell proliferation and biological inheritance.
• Understanding replication origins is key to deciphering DNA replication regulation.
• Recent genome-wide studies have significantly increased the number of identified eukaryotic replication origins.

Purpose of the Study:

• To construct a comprehensive database of eukaryotic replication origins.
• To facilitate a deeper understanding of the nature and regulation of eukaryotic replication origins.

Main Methods:

• Compilation of eukaryotic replication origins identified through genome-wide analyses.
• Data collection from six eukaryotic organisms: humans, mice, Arabidopsis thaliana, Kluyveromyces lactis, Schizosaccharomyces pombe, and Drosophila melanogaster.

Main Results:

• The Database of Eukaryotic ORIs (DeOri) was created, housing identified eukaryotic replication origins.
• A total of 16,145 replication origins were collected from the six studied organisms.
• Specific counts include 433 (human), 7489 (mouse), 1543 (A. thaliana), 148 (K. lactis), 348 (S. pombe), and 6184 (D. melanogaster).

Conclusions:

• The DeOri database provides a valuable resource for studying eukaryotic replication origins.
• This compilation aids in understanding the mechanisms regulating DNA replication across diverse eukaryotic species.