[Effect of isoflurane and enflurane on ICG-clearance]

We performed ICG-test (indo-cyanine green test) during surgery to study the effect of isoflurane and enflurane on ICG clearance in human. When the systolic arterial pressure (SAP) was maintained at 70% of the preoperative base line value, a significant decrease in ICG clearance occurred in the patients who received enflurane. Isoflurane, on the contrary, did not cause such a decrease in the ICG clearance. We conclude that isoflurane may restore either the blood flow to the liver or the liver function and the liver may remove ICG from the blood much better under isoflurane than under enflurane.