Distance from the growth plate and Its relation to the outcome of unicameral bone cyst treatment

Insights

The distance of unicameral bone cysts from the growth plate predicts treatment success. Cysts over 2 cm from the growth plate healed completely, while those closer did not, regardless of treatment method.

Area of Science:

  • Pediatric Orthopedics
  • Skeletal Biology
  • Surgical Outcomes Research

Background:

  • Unicameral bone cysts (UBCs) are common benign bone lesions in children.
  • Treatment outcomes for UBCs are variable and unpredictable.
  • Predictive factors for successful UBC treatment require further investigation.

Purpose of the Study:

  • To evaluate the predictive value of the distance between the growth plate and unicameral bone cysts for treatment outcomes.
  • To determine if a specific distance threshold can indicate successful healing.
  • To inform clinical decision-making for UBC management.

Main Methods:

  • Retrospective analysis of 39 interventions for UBCs in 19 pediatric patients (1994-2003).
  • Categorization of cysts based on distance from the growth plate (<2 cm vs. >2 cm).
  • Assessment of treatment success (complete healing) across various intervention modalities.

Main Results:

  • Complete healing was achieved in 10 out of 19 patients.
  • Nine of the 10 successfully treated patients had cysts located more than 2 cm from the growth plate.
  • One patient with a cyst <2 cm from the growth plate achieved healing via epiphyseodesis.

Conclusions:

  • The distance of a unicameral bone cyst from the growth plate is a significant predictor of treatment outcome.
  • Cysts located more than 2 cm from the growth plate demonstrate a higher likelihood of complete healing.
  • A 2 cm distance threshold may serve as a valuable clinical tool for predicting UBC treatment success.
Abstract

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...