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Magnetic resonace-based attenuation correction for micro-single-photon emission computed tomography.

Vincent Keereman1, Yves Fierens, Christian Vanhove

  • 1Ghent University Hospital-IBiTech De Pintelaan 185, 9000 Ghent, Belgium. Vincent.Keereman@ugent.be

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Accurate quantification in micro-single-photon emission computed tomography (micro-SPECT) requires attenuation correction. Ultrashort echo time (UTE) magnetic resonance (MR) imaging provides the best results for generating attenuation maps, improving accuracy.

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Biomedical Engineering

Background:

  • Accurate quantification in micro-single-photon emission computed tomography (micro-SPECT) relies on attenuation correction.
  • Traditional methods use micro-computed tomography (micro-CT), but deriving attenuation maps from magnetic resonance (MR) images is challenging due to poor visibility of bone and lung in conventional MR.

Purpose of the Study:

  • To evaluate the feasibility and accuracy of MR-based attenuation correction for micro-SPECT imaging.
  • To compare the performance of different MR-based attenuation correction methods, including ultrashort echo time (UTE) sequences.

Main Methods:

  • Acquired micro-SPECT, micro-CT, and MR images from 18 rats using various tracers for different organs.
  • Reconstructed micro-SPECT images using no correction, micro-CT-based correction, and three MR-based correction methods (uniform, non-UTE, and UTE).
  • Calculated average differences compared to micro-CT-based reconstructions to assess accuracy.

Main Results:

  • Ultrashort echo time (UTE)-MR-based attenuation correction demonstrated the best performance, with average errors of ≤ 8% in brain scans and ≤ 3% in body scans.
  • MR-based attenuation correction showed nonsignificant differences for body scans and significantly reduced errors compared to uncorrected scans (≥ 15% brain, ≥ 25% body).
  • Uniform MR maps resulted in errors of ≤ 6% in body scans.

Conclusions:

  • Attenuation correction is essential for accurate quantification in micro-SPECT.
  • MR-based attenuation correction is feasible and effective.
  • UTE-MR-based attenuation correction is recommended for precise quantitative micro-SPECT imaging.