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Updated: May 23, 2026
09:10
Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
Rage signalling promotes intestinal tumourigenesis.
J Heijmans1, N V J A Büller, E Hoff
1Tytgat Institute for Liver & Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
Oncogene
|April 4, 2012
Summary
Colon cancer develops through cellular signals, with damage-associated molecular patterns (DAMPs) potentially promoting tumor growth. Blocking the Receptor for Advanced Glycation End Products (Rage) signaling pathway protected mice from intestinal adenomas.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Colon cancer development involves intrinsic and extrinsic cellular signals.
- Extrinsic factors include pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
- These molecules can activate the innate immune system, promoting tumor development, but receptor roles are unclear.
Purpose of the Study:
- To investigate the role of the Receptor for Advanced Glycation End Products (Rage) signaling in sporadic intestinal adenoma development.
- To determine if blocking Rage signaling impacts tumor formation in a mouse model.
Main Methods:
- Utilized a mouse model with mutations in Adenomatous Polyposis Coli (ApcMin/+) and knockout for Rage (Rage-/-).
- Assessed tumor development and progression in these genetically modified mice.
Main Results:
- ApcMin/+ Rage-/- mice showed significant protection against intestinal adenoma formation compared to controls.
- This indicates Rage signaling is critical for sporadic intestinal tumor development.
Conclusions:
- Rage signaling plays a crucial role in the multistep process of sporadic colon cancer development.
- Targeting Rage could be a potential therapeutic strategy for preventing or treating intestinal adenomas.
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