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Related Experiment Video

Updated: May 23, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Rage signalling promotes intestinal tumourigenesis.

J Heijmans¹, N V J A Büller, E Hoff

¹Tytgat Institute for Liver & Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.

|April 4, 2012

Summary

Colon cancer develops through cellular signals, with damage-associated molecular patterns (DAMPs) potentially promoting tumor growth. Blocking the Receptor for Advanced Glycation End Products (Rage) signaling pathway protected mice from intestinal adenomas.

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A Simple Device to Rapidly Prepare Whole Mounts of the Mouse Intestine

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Published on: October 27, 2015

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Last Updated: May 23, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

A Simple Device to Rapidly Prepare Whole Mounts of the Mouse Intestine

A Simple Device to Rapidly Prepare Whole Mounts of the Mouse Intestine

Published on: October 27, 2015

Area of Science:

Oncology
Immunology
Molecular Biology

Background:

Colon cancer development involves intrinsic and extrinsic cellular signals.
Extrinsic factors include pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
These molecules can activate the innate immune system, promoting tumor development, but receptor roles are unclear.

Purpose of the Study:

To investigate the role of the Receptor for Advanced Glycation End Products (Rage) signaling in sporadic intestinal adenoma development.
To determine if blocking Rage signaling impacts tumor formation in a mouse model.

Main Methods:

Utilized a mouse model with mutations in Adenomatous Polyposis Coli (ApcMin/+) and knockout for Rage (Rage-/-).
Assessed tumor development and progression in these genetically modified mice.

Main Results:

ApcMin/+ Rage-/- mice showed significant protection against intestinal adenoma formation compared to controls.
This indicates Rage signaling is critical for sporadic intestinal tumor development.

Conclusions:

Rage signaling plays a crucial role in the multistep process of sporadic colon cancer development.
Targeting Rage could be a potential therapeutic strategy for preventing or treating intestinal adenomas.