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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Published on: February 6, 2019

Optimizing SHIELD-HIT for carbon ion treatment.

David C Hansen¹, Armin Lühr, Nikolai Sobolevsky

¹Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44 Bldg 5, DK-8000 Aarhus C, Denmark. dch@ki.au.dk

Physics in Medicine and Biology

|April 4, 2012

Summary

This summary is machine-generated.

This study calibrates the SHIELD-HIT Monte Carlo code for particle therapy simulations. The updated code shows excellent agreement for carbon ions, improving accuracy in clinical ion beam treatments.

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Area of Science:

Medical Physics
Computational Physics
Nuclear Physics

Background:

The SHIELD-HIT Monte Carlo code is essential for particle therapy simulations.
Previous versions exhibited discrepancies with experimental data.

Purpose of the Study:

To enhance the accuracy of the SHIELD-HIT code for particle therapy.
To calibrate inelastic nuclear cross sections and nuclear fragmentation models for carbon ions.

Main Methods:

Calibrated inelastic nuclear cross sections using experimental data for carbon ions.
Adjusted nuclear fragmentation models for partial charge-changing cross sections in water.
Validated against fragmentation yield experiments for carbon and neon primaries.

Main Results:

Achieved excellent agreement between SHIELD-HIT simulations and experimental data for carbon primaries.
Observed good agreement for neon primaries, with minor discrepancies noted for further investigation.
Demonstrated improved simulation accuracy for clinical ion beams.

Conclusions:

The SHIELD-HIT10A version is well-suited for particle therapy simulations.
The calibration significantly improves the code's reliability for carbon ion treatments.
Further investigation is needed for neon primary simulations.