Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The omicron surge - Beginning of the pandemic's end?

Indian journal of pathology & microbiology·2023

Same author

Simplified screening and referral protocol for sinonasal mucormycosis in post COVID-19 patients.

Bulletin of the National Research Centre·2023

Same author

EDTA dependent pseudo thrombocytopenia- A diagnostic dilemma!

Indian journal of pathology & microbiology·2023

Same author

Cysticercosis: A case of missed diagnosis.

Diagnostic cytopathology·2022

Same author

Human papilloma virus infection of uterine cervix and spectrum of cervical pathology in human immunodeficiency virus/AIDS.

Journal of cancer research and therapeutics·2021

Same author

Disseminated Cryptococcosis in an Immunocompetent Child.

Turk patoloji dergisi·2017

Search research articles

Related Experiment Video

Updated: May 23, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Malignant proliferating trichilemmal tumor.

Snigdha Goyal¹, Bhawna Bhutoria Jain, Sritanu Jana

¹Department of Pathology, Burdwan Medical College, Burdwan, West Bengal, India.

Indian Journal of Dermatology

|April 4, 2012

Summary

Malignant transformation of proliferating trichilemmal tumors (PTT) is rare and often mistaken for squamous cell carcinoma. Early identification of malignant PTT is crucial for proper patient management.

Keywords:

Malignant proliferating trichilemmal tumor squamous cell carcinoma

More Related Videos

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Related Experiment Videos

Last Updated: May 23, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Area of Science:

Dermatology
Oncology
Pathology

Background:

Proliferating trichilemmal tumor (PTT) is a benign neoplasm arising from the hair follicle's outer root sheath.
Malignant transformation of PTT is exceedingly rare, posing diagnostic challenges due to overlapping features with squamous cell carcinoma.
Accurate differentiation is critical for appropriate clinical management and prognosis.

Purpose of the Study:

To highlight the rarity and diagnostic difficulties associated with malignant proliferating trichilemmal tumors.
To present a case report of a patient with a rapidly growing scalp swelling suspicious for malignant PTT.
To emphasize the importance of recognizing malignant PTT in clinical practice.

Main Methods:

Case presentation of a 75-year-old female patient.
Clinical examination and diagnostic workup (details not provided in abstract).
Review of existing literature on malignant proliferating trichilemmal tumors.

Main Results:

The case involves a rapidly growing scalp swelling in an elderly female.
Malignant PTT is a rare entity with only 39 documented cases in English literature to date.
Differential diagnosis with squamous cell carcinoma is a key challenge.

Conclusions:

Malignant transformation of PTT is an uncommon but significant event.
Distinguishing malignant PTT from squamous cell carcinoma requires careful evaluation.
Increased awareness and reporting of such cases are essential for better understanding and management.