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Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

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Related Experiment Video

Updated: May 23, 2026

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

CPPD crowned dens syndrome with clivus destruction: a case report.

Sayed Ali1, Michael Hoch, Vipulkumar Dadhania

  • 1Department of Radiology, Temple University Hospital, Philadelphia, PA 19140, USA. saychink@gmail.com

Journal of Radiology Case Reports
|April 4, 2012
PubMed
Summary

This study details a rare case of calcium pyrophosphate dihydrate (CPPD) crowned dens syndrome. The syndrome caused unusual clivus erosion, expanding its known diagnostic considerations.

Keywords:
Calcium pyrophosphate dihydrate deposition diseaseclivusdens

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Last Updated: May 23, 2026

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

Area of Science:

  • Rheumatology
  • Neurology
  • Radiology

Background:

  • Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease can manifest as crowned dens syndrome (CDS).
  • CDS typically presents with neck pain and neurological deficits, primarily affecting the upper cervical spine.

Observation:

  • A rare case of CDS in an 87-year-old male with a history of pseudogout is presented.
  • The patient exhibited characteristic clinical and radiological features of CDS.
  • Notably, significant mass effect on the clivus, including erosion and destruction, was observed, a previously undescribed finding.

Findings:

  • The observed clivus erosion and destruction represent a novel radiological manifestation of CPPD-related CDS.
  • Review of CDS and CPPD highlights the typical presentations and diagnostic criteria.
  • The case underscores the importance of considering CDS in the differential diagnosis of clivus abnormalities.

Implications:

  • This case expands the understanding of potential radiological findings in CPPD-related CDS.
  • It suggests that CDS should be considered in patients presenting with clivus destruction, especially with associated calcified soft tissue masses.
  • Further research may elucidate the mechanisms behind clivus involvement in CDS.