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Related Experiment Video

Updated: May 23, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Update on the keratoconus genetics.

Kim Nielsen¹, Jesper Hjortdal, Maria Pihlmann

¹Department of Ophthalmology, Aarhus University Hospital, Aarhus C, Denmark. kimnisen@rm.dk

Acta Ophthalmologica

|April 5, 2012

Summary

This summary is machine-generated.

Keratoconus (KC), a leading cause of corneal transplants, remains poorly understood genetically. This review reconciles diverse research findings, highlighting KC as a complex, multifactorial disease with unsolved pathological mechanisms.

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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

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Published on: November 12, 2015

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Published on: December 8, 2023

Area of Science:

Ophthalmology
Genetics
Molecular Biology

Background:

Keratoconus (KC) is a primary indication for corneal transplantation.
The genetic basis of KC remains largely elusive compared to other corneal dystrophies.
Decades of research have yielded diverse and sometimes conflicting results regarding KC's etiology.

Purpose of the Study:

To review and contextualize existing research on the genetic and molecular basis of keratoconus.
To reconcile conflicting findings in published KC research over the past two decades.
To underscore the multifactorial nature of keratoconus.

Main Methods:

Comprehensive literature review of studies on keratoconus etiology.
Analysis of published genetic and molecular biology data.
Synthesis of diverse research findings within the context of current biological understanding.

Main Results:

Apparent contradictions in research findings become coherent when viewed within a broader molecular biology context.
Keratoconus exhibits significant heterogeneity, supporting its classification as a multifactorial disease.
Despite extensive research, the precise pathological mechanisms underlying KC are yet to be fully elucidated.

Conclusions:

Keratoconus is a complex, multifactorial condition.
Reconciling diverse research data provides a clearer, albeit incomplete, picture of KC's etiology.
Further investigation is required to fully understand and potentially treat keratoconus.