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Related Experiment Video

Updated: May 23, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Trabecular meshwork in normal and pathological eyes.

Nicola Pescosolido¹, Carlo Cavallotti, Dario Rusciano

¹Department of Science Cardiovascular Respiratory and Morphological Sciences, Sapienza University of Rome, Rome, Italy.

Ultrastructural Pathology

|April 5, 2012

Summary

Glycosaminoglycans in the eye change with aging and glaucoma, showing altered hyaluronic acid and sulfated glycosaminoglycan levels. These changes impact the iridocorneal angle structures, potentially affecting intraocular pressure.

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Last Updated: May 23, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

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Published on: June 20, 2015

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

Ophthalmology
Biochemistry
Cell Biology

Background:

Glycosaminoglycans (GAGs) play crucial roles in tissue structure and function.
Alterations in GAGs are implicated in various pathological conditions.
The iridocorneal angle is vital for regulating intraocular pressure.

Purpose of the Study:

To investigate the impact of glycosaminoglycans on intraocular pressure.
To analyze GAG changes in the iridocorneal angle of healthy young, aging, and glaucoma patients.

Main Methods:

Autoptic tissue samples from the iridocorneal angle were analyzed.
Samples were divided for morphological and biochemical assessments.
Image analysis quantified morphological data, correlated with biochemical findings.

Main Results:

Glycosaminoglycans induced fibrous granular material deposition and increased electron density in the iridocorneal angle.
Hyaluronic acid content significantly decreased, while sulfated glycosaminoglycans increased.
These changes were observed in both aging and glaucoma patient groups.

Conclusions:

Glycosaminoglycans in the iridocorneal angle undergo physiological and pathological changes.
These alterations are comparable to those in other body tissues.
Changes in the trabecular meshwork's GAGs may contribute to altered aqueous humor outflow in primary open-angle glaucoma.