Study on the expression of co-stimulatory marker CD134 on CD4+ T cells in HIV-1-infected individuals

CD4+CD25+CD134+ T cells play an important role in suppressing T cell responses to foreign pathogens, including human immunodeficiency virus (HIV). Thus, we aimed to investigate an increase in these populations in HIV-1-infected individuals. In this study, we used a panel of monoclonal antibodies staining of CD3/CD4/CD25/CD134. Without antigen stimulation, the expression of CD4+CD25+CD134+ T cells in 14 HIV-1-infected and 24 healthy individuals were 4.01% and 3.21%, respectively. However, there was an increase in the expression of CD4 + CD25+CD134+ T cells in HIV-1-infected individuals (6.85%) when stimulated with gag peptide. The upregulation of CD4+CD25+CD134+ T cells in HIV-1-infected individuals may result from activation of naturally occurring or by disease-associated antigen stimulation.