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Related Experiment Videos

Liver glycogenolysis during exercise without a significant increase in cAMP.

W W Winder, J Boullier, R D Fell

    The American Journal of Physiology
    |September 1, 1979
    PubMed
    Summary

    Exercise accelerates liver glycogenolysis independently of significant increases in cyclic adenosine monophosphate (cAMP). This suggests cAMP-independent pathways control glucose release during physical activity.

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    Area of Science:

    • Physiology
    • Endocrinology
    • Exercise Metabolism

    Background:

    • Liver glycogenolysis is crucial for maintaining blood glucose levels during fasting and exercise.
    • Regulation of glycogenolysis involves hormones like glucagon and catecholamines, often mediated by cyclic adenosine monophosphate (cAMP).
    • The precise role of cAMP in exercise-induced liver glycogenolysis requires further elucidation.

    Purpose of the Study:

    • To investigate whether elevated liver cyclic adenosine monophosphate (cAMP) levels accompany accelerated liver glycogenolysis during exercise in rats.
    • To determine the relationship between exercise duration, liver glycogen depletion, and changes in liver cAMP concentrations.

    Main Methods:

    • Rats underwent a 6-week treadmill training program.
    • Trained rats performed continuous treadmill exercise for varying durations (0-120 minutes).

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  • Liver glycogen and liver cAMP levels were measured at different time points during exercise, alongside plasma glucagon and catecholamines.

    • Main Results:

    • Liver glycogen was significantly depleted within 20-90 minutes of exercise, depending on feeding status.
    • Liver cAMP levels did not increase significantly during the initial 60 minutes of exercise in fed rats.
    • A notable increase in liver cAMP occurred only after glycogen depletion, coinciding with elevated plasma glucagon and catecholamines.

    Conclusions:

    • Liver glycogenolysis during exercise in rats can proceed effectively without significant increases in liver cAMP.
    • These findings indicate the involvement of cAMP-independent mechanisms in regulating liver glucose production during physical exertion.
    • Hormonal responses like increased glucagon and catecholamines may play a role in later stages of exercise or during the transition to gluconeogenesis.