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The relationship between aortic stiffness and left ventricular dyssynchrony in hypertensive patients with preserved

Mi-Na Kim1, Seong-Mi Park, Wan-Joo Shim

  • 1Division of Cardiology, Korea University Cardiovascular Center, Korea University Anam Hospital, Seoul, Republic of Korea.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|April 5, 2012
PubMed

Insights

Arterial stiffness and increased left ventricular mass may cause diastolic dyssynchrony in hypertensive patients without heart failure. This study highlights the link between aortic stiffness and diastolic dysfunction in this population.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Left ventricular (LV) dyssynchrony is prevalent in hypertension, even without heart failure.
  • Arterial stiffness is a known contributor to elevated blood pressure and impaired ventricular function.

Purpose of the Study:

  • To investigate the association between aortic stiffness and LV dyssynchrony in hypertensive patients with preserved LV systolic function.

Main Methods:

  • Eighty hypertensive patients (LV ejection fraction > 50%) and 30 controls were assessed.
  • LV systolic and diastolic dyssynchrony indices (Ts-SD, Te-SD, Ts-Max, Te-Max) were measured using echocardiography.
  • Aortic stiffness index was calculated from aortic dimensions and blood pressure.

Main Results:

  • No significant relationship was found between LV systolic and diastolic dyssynchrony indices.
  • Aortic stiffness parameter correlated with LV mass index (LVMI), E/A ratio, and LV diastolic dyssynchrony (Te-Max).
  • Multiple regression revealed Te-Max was significantly related to aortic strain and aortic stiffness index; LVMI was related to aortic distensibility.

Conclusions:

  • Increased LV mass and arterial stiffness are potential contributors to LV diastolic dyssynchronous changes in hypertensive patients.
  • Findings suggest a link between arterial stiffness, LV remodeling, and diastolic dysfunction in hypertension.

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