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Fracture risk by HIV infection status in perinatally HIV-exposed children

George K Siberry1, Hong Li, Denise Jacobson

  • 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-7510, USA. siberryg@mail.nih.gov

AIDS Research and Human Retroviruses
|April 5, 2012
PubMed

Insights

This study found that fracture incidence in children with human immunodeficiency virus (HIV) was similar to that in HIV-exposed, uninfected children. These findings suggest no substantially increased fracture risk for HIV-infected children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Pediatric fractures are a concern, and understanding risk factors is crucial for preventative care.
  • Human immunodeficiency virus (HIV) infection can impact bone health, but data on fracture risk in children is limited.

Purpose of the Study:

  • To investigate the incidence of fractures in children with HIV compared to HIV-exposed, uninfected (HEU) children.
  • To determine if HIV infection is associated with an increased risk of fractures in pediatric populations.

Main Methods:

  • A prospective, multicenter cohort study (PACTG 219/219C) in the United States was utilized.
  • The study followed HIV-infected children and a comparable group of HEU children.
  • The primary outcome measured was the occurrence of a first fracture during the defined risk period.

Main Results:

  • Nine fractures were observed in 7 out of 1326 HIV-infected children.
  • Two fractures occurred in 2 out of 649 HEU children.
  • Incidence rates were 1.2 per 1000 person-years for HIV-infected children and 1.1 per 1000 person-years for HEU children, with an incidence rate ratio of 1.1 (95% CI 0.2, 5.5).

Conclusions:

  • The study found no evidence of a substantially increased risk of fracture in HIV-infected children compared to HEU children.
  • These findings contribute to understanding bone health in pediatric HIV infection.
  • Further research may explore specific factors influencing bone health in this population.

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