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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: May 23, 2026

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
09:33

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

Cadmium and its epigenetic effects.

B Wang1, Y Li, C Shao

  • 1Department of Pathophysiology, Prostate Diseases Prevention and Treatment Research Center, Norman Bethune College of Medicine, Jilin University, Changchun, China.

Current Medicinal Chemistry
|April 5, 2012
PubMed
Summary
This summary is machine-generated.

Cadmium exposure may cause cancer and cardiovascular diseases by altering epigenetic mechanisms. These changes, including DNA methylation and histone modifications, can be passed to future generations, impacting long-term health.

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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Related Experiment Videos

Last Updated: May 23, 2026

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
09:33

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Area of Science:

  • Environmental Toxicology
  • Epigenetics
  • Molecular Biology

Background:

  • Cadmium (Cd) is a toxic metal posing significant health risks, including cancer and cardiovascular diseases, with poorly understood molecular underpinnings.
  • Epigenetics involves heritable changes in gene expression without altering DNA sequence, mediated by DNA methylation, histone modifications, and microRNAs.
  • Aberrant epigenetic modifications are implicated in various cancers and chronic diseases.

Purpose of the Study:

  • To review in vitro and in vivo evidence of cadmium's epigenetic effects.
  • To explore the potential role of epigenetic mechanisms in cadmium-induced toxicity and carcinogenicity.
  • To highlight the importance of environmental epigenomics in understanding long-term health effects of cadmium exposure.

Main Methods:

  • Literature review of in vitro and in vivo studies on cadmium's epigenetic effects.
  • Analysis of findings linking cadmium exposure to cellular and tissue alterations.
  • Synthesis of evidence regarding epigenetic changes associated with cadmium-induced malignant transformation and pathological proliferation.

Main Results:

  • Cadmium exposure induces various epigenetic changes in plant and mammalian cells.
  • Epigenetic alterations are observed in association with cadmium-induced malignant cell transformation.
  • Cadmium exposure correlates with pathological proliferation of tissues, suggesting epigenetic involvement.

Conclusions:

  • Epigenetic mechanisms are likely involved in cadmium's toxic effects, particularly its carcinogenicity.
  • Cadmium-induced epigenetic changes may contribute to the development of cancers and chronic diseases.
  • Future research should focus on environmental epigenomics to elucidate long-term health impacts of cadmium exposure.