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Updated: May 23, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Synthesis of the bridging framework of phragmalin-type limonoids
Terry P Lebold1, Gary M Gallego, Christopher J Marth
1Department of Chemistry, University of California, Berkeley, California 94720, USA.
Abstract:
An efficient synthesis of the octahydro-1H-2,4-methanoindene core of phragmalin-type limonoids, such as xyloccensins O and P, is reported. The success of the synthetic route is predicated on the use of network analysis in the retrosynthetic analysis and a Diels-Alder reaction for the synthesis of a key hydrindanone derivative.
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