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Related Concept Videos

Cohesins02:20

Cohesins

Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of homologous...
Cohesins02:20

Cohesins

Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of homologous...
Condensins02:15

Condensins

Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
Condensins02:15

Condensins

Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...

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Related Experiment Video

Updated: May 23, 2026

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline
09:14

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline

Published on: September 13, 2022

Cohesin in determining chromosome architecture.

Christian H Haering1, Rolf Jessberger

  • 1Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany. christian.haering@embl.de

Experimental Cell Research
|April 5, 2012
PubMed
Summary

The cohesin ring complex is crucial for organizing chromosomes. This review details its structural roles in cell division and interphase, highlighting its dynamic nature in DNA management.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Cells utilize ring-like protein complexes for DNA dynamics.
  • The cohesin ring complex is a large, dynamic structure involved in multiple nuclear processes.
  • Cohesin's structure and functions are key to understanding chromosome organization.

Purpose of the Study:

  • To review the role of the cohesin ring in chromosome structuring.
  • To focus on cohesin's functions during cell division (mitosis and meiosis) and interphase.
  • To highlight cohesin's dynamic properties and varied forms in nuclear processes.

Main Methods:

  • Literature review of cohesin's functions.
  • Analysis of cohesin's structural contributions to chromosome architecture.

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Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

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Related Experiment Videos

Last Updated: May 23, 2026

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline
09:14

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline

Published on: September 13, 2022

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

  • Synthesis of data on cohesin's involvement in DNA dynamics.

    • Main Results:

    • Cohesin is central to chromosome architecture due to its size and dynamic nature.
    • The cohesin ring can adopt different forms, enabling diverse functions.
    • Cohesin plays critical roles in both mitotic and meiotic cell divisions.
    • Cohesin also influences chromosome structure during interphase.

    Conclusions:

    • The cohesin ring complex is a fundamental determinant of chromosome architecture.
    • Its dynamic and adaptable nature underlies its diverse roles in DNA management.
    • Understanding cohesin is essential for comprehending cell division and nuclear organization.