Cohesin in determining chromosome architecture
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Updated: May 23, 2026

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline
Published on: September 13, 2022
Christian H Haering1, Rolf Jessberger
1Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany. christian.haering@embl.de
Abstract:
Cells use ring-like structured protein complexes for various tasks in DNA dynamics. The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes. This review focuses on cohesin's role in structuring chromosomes during mitotic and meiotic cell divisions and during interphase.
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