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Updated: May 23, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Anhydrotic ectodermal dysplasia associated to mannose-binding lectin deficiency]
I Delgado Pecellín1, Y Castillo Reguera, C Delgado Pecellín
1Unidad de Neumología y Alergia, Hospital Infantil Virgen del Rocío, Sevilla, España. idelpe@gmail.com
Abstract:
Mannose-binding lectin (MBL) is a serum protein of the innate immune system. MBL enhances opsonophagocytosis by binding to carbohydrates expressed by multiple pathogens. MBL deficiency is due to polymorphisms in the structural and promoter sequences of the MBL2 gene and is associated with variety of recurrent infections, including respiratory tract infections. We present a case of anhidrotic ectodermal dysplasia associated with severe mannose-binding lectin deficiency, never described in patients with anhidrotic ectodermal dysplasia.
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